GH Secretagogues Research Guide

Hexarelin Acetate: Mechanism, Handling & Research Guide

Also known as: Hexarelin, Hexarelin acetate, EP-23905, EP23905, Examorelin, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2

Key Facts

Hexarelin Acetate is a gh secretagogues research peptide (C47H58N12O6, MW 887.0 g/mol). Hexarelin is a synthetic hexapeptide growth hormone secretagogue studied for GH release and cardiac tissue signaling. It is supplied as a lyophilized powder for laboratory and in-vitro research use only — not for human consumption.

Classification	Synthetic hexapeptide growth hormone secretagogue; dual GHS-R1a / CD36 receptor agonist
Molecular Formula	C47H58N12O6
Molecular Weight	887.0 g/mol
CAS Number	140703-51-1
Research Half-Life	Not well characterized in humans; reported as short-acting (on the order of tens of minutes) in published animal pharmacokinetic studies
Form	Lyophilized powder
Research Category	GH Secretagogues

What is Hexarelin Acetate?

Hexarelin is a synthetic six-amino-acid peptide that acts as a potent growth hormone secretagogue, stimulating GH release through the ghrelin/GHS-R1a receptor. Beyond its pituitary effects, research has explored hexarelin's interaction with the CD36 receptor in cardiovascular tissue, where it has been studied for potential cytoprotective and anti-fibrotic signaling in cardiac models. It is investigated in growth hormone axis research and comparative GHS studies alongside GHRP-6 and ipamorelin. Supplied as a lyophilized powder for in-vitro and laboratory research use only.

Hexarelin Acetate Research Applications

In published and preclinical research, Hexarelin Acetate has been studied across the following areas:

Growth hormone secretagogue research
Ghrelin/GHS-R receptor signaling
Cardiac tissue and CD36 pathway studies
Comparative GHS research

Hexarelin Acetate in Research: Study Context

Published literature characterizes hexarelin (EP-23905, examorelin) as a methylated, metabolically stabilized analogue of the GHRP-6 family that potently stimulates GH release via the GHS-R1a receptor, and that also engages the scavenger receptor CD36 in cardiac tissue - a non-GHS-R pathway linked in animal models to cardioprotective signaling after ischemia/reperfusion and myocardial infarction (Imbimbo/Deghenghi; Bodart; Tivesten). For laboratory research the lyophilized acetate salt is reconstituted with bacteriostatic water to a defined concentration such as 5.0 mg/mL (5 mg vial in 1 mL), stored sealed at 2-8C, and protected from light. This product is for in-vitro and laboratory research use only, is not FDA-approved, and carries no human concentration; investigators should reference the primary literature and document each lot's Certificate of Analysis (COA).

How Hexarelin Acetate Compares

Researchers frequently evaluate Hexarelin Acetate alongside related compounds:

Hexarelin Acetate vs GHRP-6 — Parent-family hexapeptide; hexarelin is the methylated, more potent and more stable analogue with added CD36 cardiac binding
Hexarelin Acetate vs Ipamorelin — Highly selective GHS-R1a agonist used when clean GH signaling is needed, versus hexarelin's dual GHS-R1a/CD36 activity
Hexarelin Acetate vs Sermorelin Acetate — GHRH-receptor agonist representing the complementary GH-release pathway to hexarelin's ghrelin-receptor mechanism

Hexarelin Acetate — Frequently Asked Questions

What distinguishes hexarelin from GHRP-6 in the literature?

Hexarelin (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) carries a 2-methyl-tryptophan substitution that increases potency and metabolic stability relative to GHRP-6. Beyond GH release through GHS-R1a, hexarelin is uniquely characterized as binding the cardiac scavenger receptor CD36, a property explored in cardiovascular research models.

What cardiac research has used hexarelin?

Studies have identified CD36 as a cardiac receptor mediating hexarelin's effects and reported preservation of left-ventricular function, reduced cardiomyocyte apoptosis, and reduced fibrosis in rodent models of myocardial infarction and ischemia/reperfusion. These are preclinical mechanistic findings, not therapeutic claims.

Is hexarelin approved for clinical use?

No. Hexarelin acetate is not FDA-approved and is supplied strictly for in-vitro and laboratory research use only. The published record concerns experimental endocrine and cardiovascular pharmacology. Each research lot should ship with a Certificate of Analysis confirming identity and purity by HPLC and mass spectrometry.

Is Hexarelin Acetate legal to buy for research?

Hexarelin Acetate is sold in the United States as a research chemical for laboratory and in-vitro use only. It is not approved by the FDA for human use and is not sold for human consumption. Researchers are responsible for compliance with all applicable federal, state, and institutional regulations.

Does Hexarelin Acetate come with a Certificate of Analysis?

Yes. Every batch of Hexarelin Acetate from Elyte Peptides ships with a third-party Certificate of Analysis (COA) documenting identity and HPLC purity (≥98%), so research results can be traced to a verified lot.

What is Hexarelin Acetate?

Hexarelin is a synthetic hexapeptide growth hormone secretagogue studied for GH release and cardiac tissue signaling. It is supplied in 5mg vials and intended strictly for in-vitro and laboratory research use only.

How should Hexarelin Acetate be stored?

Hexarelin Acetate should be stored at -20°C for long-term storage or 2-8°C for short-term use. Keep the vial sealed and protected from light, moisture, and repeated freeze-thaw cycles. Once reconstituted, store at 2-8°C and use within 30 days.

What purity is Hexarelin Acetate?

Hexarelin Acetate is manufactured to a minimum purity of ≥98% as verified by HPLC analysis, with identity confirmed by mass spectrometry. Each batch ships with a Certificate of Analysis (COA).

Research References

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