Research Comparison

Hexarelin Acetate vs Ipamorelin

In Short

Hexarelin Acetate is synthetic hexapeptide growth hormone secretagogue; dual ghs-r1a / cd36 receptor agonist; Ipamorelin is selective growth-hormone secretagogue (ghrelin-receptor agonist). Both are supplied as lyophilized powders for laboratory and in-vitro research use only. The table below compares their molecular data, half-life and research focus side by side.

	Hexarelin Acetate	Ipamorelin
Classification	Synthetic hexapeptide growth hormone secretagogue; dual GHS-R1a / CD36 receptor agonist	Selective growth-hormone secretagogue (ghrelin-receptor agonist)
Molecular formula	C47H58N12O6	C38H49N9O5
Molecular weight	887.0 g/mol	711.87 g/mol
CAS number	140703-51-1	170851-70-4
Research half-life	Not well characterized in humans; reported as short-acting (on the order of tens of minutes) in published animal pharmacokinetic studies	~2 hours in preclinical models
Primary research focus	Growth hormone secretagogue research	Bone metabolism and structural integrity
Form	Lyophilized powder	Lyophilized powder
Price from	$87.50	$40.00

Hexarelin Acetate

Hexarelin is a synthetic six-amino-acid peptide that acts as a potent growth hormone secretagogue, stimulating GH release through the ghrelin/GHS-R1a receptor. Beyond its pituitary effects, research has explored hexarelin's interaction with the CD36 receptor in cardiovascular tissue, where it has been studied for potential cytoprotective and anti-fibrotic signaling in cardiac models. It is investigated in growth hormone axis research and comparative GHS studies alongside GHRP-6 and ipamorelin. Supplied as a lyophilized powder for in-vitro and laboratory research use only.

Full Hexarelin Acetate research guide

Ipamorelin

Ipamorelin is a synthetic pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH2) that acts as a selective agonist of the growth hormone secretagogue receptor (GHS-R1a/ghrelin receptor). Its mechanism involves binding the ghrelin receptor on anterior pituitary somatotrophs to trigger calcium influx and GH granule exocytosis. What distinguishes ipamorelin from earlier ghrelin mimetics is its remarkable selectivity: clinical studies by Raun et al. (European Journal of Endocrinology, 1998) demonstrated that ipamorelin stimulates GH release in a concentration-dependent manner without significantly affecting cortisol, prolactin, FSH, LH, or TSH levels, even at high concentrations. This selectivity profile makes it one of the cleanest GH secretagogues available for research. In bone metabolism research, Anderson et al. (Bone, 2001) showed that ipamorelin use in ovariectomized rat models increased bone mineral content and bone formation markers, suggesting anabolic effects on skeletal tissue independent of IGF-1 elevation. The peptide has also been studied in post-operative recovery models, where it demonstrated prokinetic effects on gastric motility. Compared to GHRP-6 and GHRP-2, which also activate the ghrelin receptor but additionally stimulate appetite and affect cortisol/prolactin levels, ipamorelin provides a more isolated GH response. Store lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C for up to 28 days. Ipamorelin is investigated by endocrinology labs, bone metabolism research centers, orthopedic research departments, and gastrointestinal motility researchers.

Full Ipamorelin research guide

Frequently Asked Questions

What is the main difference between Hexarelin Acetate and Ipamorelin?

Hexarelin Acetate is classified as synthetic hexapeptide growth hormone secretagogue; dual ghs-r1a / cd36 receptor agonist, while Ipamorelin is selective growth-hormone secretagogue (ghrelin-receptor agonist). They are distinct research compounds with different mechanisms — the comparison table above sets out the molecular and pharmacokinetic differences side by side.

Can Hexarelin Acetate and Ipamorelin be studied together?

Some research protocols evaluate related peptides in combination, and research blends exist. Combination study design depends entirely on the research question and model. Both compounds are supplied for laboratory and in-vitro research use only — not for human use.

Are Hexarelin Acetate and Ipamorelin legal to buy for research?

Both are sold in the United States as research chemicals for laboratory and in-vitro use only. Neither is FDA-approved for human use. Researchers are responsible for compliance with all applicable regulations.

Buy Hexarelin Acetate

From $87.50 — ≥98% HPLC, COA included.

Buy Ipamorelin

From $40.00 — ≥98% HPLC, COA included.

Research Use Only. This comparison summarizes published research. It is not medical advice. Neither compound is for human consumption or FDA-approved.