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PT-141 (Bremelanotide) 10mg - Research Peptide
Sexual Wellness 10mg

PT-141 (Bremelanotide)

$79.00 In Stock

Melanocortin receptor agonist for sexual function and immune research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Melanocortin receptor agonist for sexual function and immune research.

PT-141, also known as Bremelanotide, is a cyclic heptapeptide melanocortin receptor agonist derived from the alpha-melanocyte-stimulating hormone (alpha-MSH) analogue Melanotan II. Unlike PDE5 inhibitors that act on vascular smooth muscle, PT-141 operates centrally through melanocortin-4 receptor (MC4R) activation in the hypothalamus and limbic system, initiating downstream dopaminergic signaling pathways associated with arousal and sexual motivation. Phase III clinical trials conducted by Palatin Technologies and published in The Journal of Sexual Medicine demonstrated that PT-141 administration produced statistically significant increases in satisfying sexual events and desire scores in premenopausal women with hypoactive sexual desire disorder (HSDD). Research by Diamond et al. (2006) in the International Journal of Impotence Research showed efficacy in male subjects who had not responded to PDE5 inhibitor therapy, suggesting a fundamentally different mechanism of action. Additional preclinical studies have identified potential roles in hemorrhagic shock models, where MC receptor activation provided protective effects on organ perfusion. Compared to sildenafil (Viagra) and tadalafil (Cialis), which are peripherally acting vasodilators, PT-141 is unique in its central nervous system mechanism. This distinction is significant because it suggests PT-141 may address desire-based dysfunction rather than purely mechanical erectile function. Melanotan II, its parent compound, activates multiple MC receptors non-selectively, while PT-141 shows preferential MC4R and MC1R activity. Store lyophilized PT-141 at -20°C. Reconstitute with bacteriostatic water and keep at 2-8°C, using within 4 weeks. PT-141 is investigated by sexual medicine researchers, neuroendocrinologists, and emergency medicine scientists studying melanocortin-based interventions.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Sexual dysfunction and arousal research
  • Hemorrhagic protection studies
  • Immune modulation via MC-1R
  • DNA repair and cancer prevention

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C50H68N14O10
Molecular Weight
1025.18 g/mol
CAS Number
189691-06-3

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is PT-141 (Bremelanotide) and how does it work?
PT-141 (Bremelanotide) is a cyclic heptapeptide that acts as a non-selective agonist of melanocortin receptors, primarily MC-3R and MC-4R. Unlike PDE5 inhibitors (which act on vascular smooth muscle), PT-141 works through central nervous system pathways — activating melanocortin receptors in the hypothalamus to influence sexual arousal signaling. It was derived from Melanotan II through the removal of the C-terminal amide.
What research has been done on PT-141?
PT-141 received FDA approval in 2019 (as Vyleesi) for hypoactive sexual desire disorder in premenopausal women. Phase 3 clinical trials (published in Obstetrics & Gynecology) demonstrated statistically significant improvements in sexual desire scores. Earlier research explored its efficacy in male erectile dysfunction. Preclinical studies have also investigated PT-141's role in hemorrhagic shock protection through MC-1R activation and its immunomodulatory properties.
How does PT-141 compare to Melanotan 2?
PT-141 was derived from Melanotan 2 but with important differences. Melanotan 2 activates all five melanocortin receptor subtypes, producing pigmentation (MC-1R), sexual arousal (MC-3R/MC-4R), and appetite effects. PT-141 was developed to be more selective for MC-3R and MC-4R, reducing pigmentation side effects. PT-141 also has the advantage of FDA approval and more extensive human clinical trial data than Melanotan 2.
What is the recommended reconstitution protocol for PT-141?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water for a 5mg/mL solution. PT-141 dissolves within 2-3 minutes (molecular weight 1025.18 g/mol). Add water along the vial wall slowly. Store reconstituted solution at 2-8°C and use within 30 days.
What purity testing is performed on PT-141?
PT-141 undergoes HPLC analysis for minimum 98% purity, with specific attention to cyclic peptide integrity (incomplete cyclization reduces bioactivity). Mass spectrometry confirms the molecular weight (1025.18 g/mol). Amino acid analysis, endotoxin testing, and residual solvent screening are performed. A Certificate of Analysis (COA) is provided with every batch.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.