MOTS-C

Description

Mitochondrial-derived peptide for metabolic regulation and cellular energy research.

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino acid peptide encoded within the mitochondrial genome, specifically within the 12S rRNA gene. Its primary mechanism of action involves activation of the AMPK pathway, which regulates cellular energy homeostasis by promoting glucose uptake and fatty acid oxidation independent of insulin signaling. Research published by Lee et al. (Cell Metabolism, 2015) demonstrated that MOTS-c administration in diet-induced obese mice significantly improved glucose tolerance and reduced fat accumulation without altering food intake. Subsequent studies from the same USC laboratory showed that MOTS-c levels decline with age in human plasma, and that exercise increases circulating MOTS-c levels, suggesting it functions as a mitochondrial-derived exercise mimetic. Unlike traditional metabolic peptides that target specific membrane receptors, MOTS-c is unique in that it translocates to the nucleus under metabolic stress to regulate nuclear gene expression, particularly genes involved in the methionine-folate cycle and de novo purine biosynthesis. Compared to other mitochondrial-derived peptides like humanin, MOTS-c appears more specifically involved in metabolic regulation rather than cytoprotection. The lyophilized peptide should be stored at -20C and protected from light; reconstitute with bacteriostatic water and store reconstituted solutions at 2-8C for up to 21 days. MOTS-c is primarily researched by aging biology laboratories, exercise physiology departments, and mitochondrial medicine research centers investigating metabolic signaling peptides.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 40mg of research-grade material.

Research Applications

• Glucose regulation and insulin sensitivity
• Skeletal muscle energy and endurance
• Fat oxidation and adipose tissue studies
• Longevity and age-related health research

Specifications

Size

40mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Formula

C101H152N28O22S2

Molecular Weight

2174.64 g/mol

CAS Number

1627580-64-6

Sequence

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection