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AOD-9604 5mg - Research Peptide
Weight Management 5mg

AOD-9604

$75.00 In Stock

Synthetic hGH fragment 176-191 analogue for lipid metabolism research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Synthetic hGH fragment 176-191 analogue for lipid metabolism research.

AOD-9604 is a modified 16-amino acid fragment corresponding to the C-terminal region (residues 176-191) of human growth hormone, with a tyrosine substitution that enhances its lipolytic activity. Its mechanism of action involves stimulating lipolysis and inhibiting lipogenesis in adipose tissue through a pathway distinct from the GH receptor, meaning it does not promote IGF-1 elevation or the diabetogenic effects associated with full-length growth hormone. Research conducted at Monash University by Ng et al. (Obesity Research, 2000) demonstrated that AOD-9604 reduced body fat in obese Zucker rats without affecting glucose tolerance or inducing growth-promoting effects. A subsequent human clinical trial (Stier et al., 2013) examined oral formulations and found the compound was well-tolerated, though weight loss results were modest compared to injectable administration in preclinical models. AOD-9604 was granted GRAS (Generally Recognized As Safe) status by the FDA in 2014 for use as a food supplement ingredient, distinguishing it from most peptides in its regulatory profile. Compared to full-length hGH, AOD-9604 offers a more targeted approach to fat metabolism research without the broad anabolic and insulin-resistance concerns. Additional preclinical studies suggest potential applications in cartilage repair and osteoarthritis models. Store the lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C, using reconstituted material within 21 days. AOD-9604 is studied by metabolic research laboratories, sports science institutions, and orthopedic research groups investigating cartilage regeneration.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 5mg of research-grade material.

Research Applications

  • Lipolysis and fat metabolism studies
  • Adipocyte size reduction research
  • Glucose and insulin regulation
  • Body composition optimization

Specifications

Size
5mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is AOD-9604 and how does it work?
AOD-9604 is a synthetic peptide fragment corresponding to amino acids 176-191 of human growth hormone (hGH), with a tyrosine residue added at the N-terminus. It mimics the lipolytic (fat-metabolizing) activity of hGH without affecting blood sugar or growth. In preclinical models, AOD-9604 has been observed to stimulate lipolysis and inhibit lipogenesis by interacting with the beta-3 adrenergic receptor pathway.
What research has been done on AOD-9604?
AOD-9604 was originally developed at Monash University in Australia. Published research in the Journal of Endocrinology demonstrated its lipolytic effects in obese Zucker rats without diabetogenic activity. Phase 2 clinical studies in humans showed reductions in body fat. The compound also received GRAS (Generally Recognized as Safe) status from the FDA for use in food applications, and separate preclinical studies have examined its effects on cartilage repair.
How does AOD-9604 compare to HGH Fragment 176-191?
AOD-9604 and HGH Fragment 176-191 share the same amino acid sequence from human growth hormone but AOD-9604 includes an additional C-terminal disulfide bond (Cys-182 to Cys-189) that stabilizes its structure. This modification gives AOD-9604 improved stability and potentially greater bioactivity in research settings compared to the linear hGH fragment.
What is the recommended reconstitution protocol for AOD-9604?
For this 5mg vial, reconstitute with 1mL of bacteriostatic water for a 5mg/mL solution. AOD-9604 is a relatively small peptide and dissolves quickly (1-2 minutes). Add the water slowly along the glass wall to avoid foaming. Store reconstituted solution at 2-8°C and use within 30 days.
What purity testing is performed on AOD-9604?
Each AOD-9604 batch is analyzed by HPLC to ensure minimum 98% purity. Identity verification is performed via electrospray mass spectrometry. Additional quality controls include residual solvent analysis, water content by Karl Fischer titration, and bacterial endotoxin testing. Every vial ships with a Certificate of Analysis (COA).

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.