Research Comparison

AOD-9604 vs HGH Frag 176-191

In Short

AOD-9604 is modified c-terminal fragment of human growth hormone; HGH Frag 176-191 is c-terminal human growth hormone fragment (lipolytic fragment); the optimized tyr-modified analog is aod9604. Both are supplied as lyophilized powders for laboratory and in-vitro research use only. The table below compares their molecular data, half-life and research focus side by side.

	AOD-9604	HGH Frag 176-191
Classification	Modified C-terminal fragment of human growth hormone	C-terminal human growth hormone fragment (lipolytic fragment); the optimized Tyr-modified analog is AOD9604
Molecular formula	—	C78H125N23O23S2
Molecular weight	—	1817.1 g/mol
CAS number	—	66004-57-7
Research half-life	Short circulating half-life in preclinical models	Reported short circulating half-life on the order of minutes in pharmacokinetic work on the related AOD9604 analog; precise figures vary by route and study.
Primary research focus	Lipolysis and fat metabolism studies	Lipolysis and fat metabolism research
Form	Lyophilized powder	Lyophilized powder
Price from	$44.00	$50.00

AOD-9604

AOD-9604 is a modified 16-amino acid fragment corresponding to the C-terminal region (residues 176-191) of human growth hormone, with a tyrosine substitution that modulates its lipolytic activity. Its mechanism of action involves stimulating lipolysis and inhibiting lipogenesis in adipose tissue through a pathway distinct from the GH receptor, meaning it does not promote IGF-1 elevation or the diabetogenic effects associated with full-length growth hormone. Research conducted at Monash University by Ng et al. (Obesity Research, 2000) demonstrated that AOD-9604 reduced body fat in obese Zucker rats without affecting glucose tolerance or inducing growth-promoting effects. A subsequent human clinical trial (Stier et al., 2013) examined oral formulations and found the compound was well-tolerated, though metabolic-pathway research results were modest compared to research-grade use in preclinical models. AOD-9604 was granted GRAS (Generally Recognized As Safe) status by the FDA in 2014 for use as a food supplement ingredient, distinguishing it from most peptides in its regulatory profile. Compared to full-length hGH, AOD-9604 offers a more targeted approach to fat metabolism research without the broad anabolic and insulin-resistance concerns. Additional preclinical studies suggest potential applications in cartilage repair and osteoarthritis models. Store the lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C, using reconstituted material within 21 days. AOD-9604 is studied by metabolic research laboratories, sports science institutions, and orthopedic research groups investigating cartilage regeneration.

Full AOD-9604 research guide

HGH Frag 176-191

HGH Fragment 176-191 corresponds to the final 16 amino acids of the human growth hormone molecule, a region associated with the hormone's fat-metabolizing activity. In preclinical research it has been investigated for its ability to stimulate lipolysis and inhibit lipogenesis in adipose tissue while showing little effect on IGF-1 levels, insulin sensitivity, or skeletal growth pathways. This selectivity has made it a subject of interest in metabolic and body-composition research models. Supplied as a lyophilized powder for in-vitro and laboratory research use only; not for human consumption.

Full HGH Frag 176-191 research guide

Frequently Asked Questions

What is the main difference between AOD-9604 and HGH Frag 176-191?

AOD-9604 is classified as modified c-terminal fragment of human growth hormone, while HGH Frag 176-191 is c-terminal human growth hormone fragment (lipolytic fragment); the optimized tyr-modified analog is aod9604. They are distinct research compounds with different mechanisms — the comparison table above sets out the molecular and pharmacokinetic differences side by side.

Can AOD-9604 and HGH Frag 176-191 be studied together?

Some research protocols evaluate related peptides in combination, and research blends exist. Combination study design depends entirely on the research question and model. Both compounds are supplied for laboratory and in-vitro research use only — not for human use.

Are AOD-9604 and HGH Frag 176-191 legal to buy for research?

Both are sold in the United States as research chemicals for laboratory and in-vitro use only. Neither is FDA-approved for human use. Researchers are responsible for compliance with all applicable regulations.

Buy AOD-9604

From $44.00 — ≥98% HPLC, COA included.

Buy HGH Frag 176-191

From $50.00 — ≥98% HPLC, COA included.

Research Use Only. This comparison summarizes published research. It is not medical advice. Neither compound is for human consumption or FDA-approved.