Pinealon

Description

Synthetic tripeptide bioregulator for neuroprotection and circadian research.

Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg (EDR) that belongs to the Khavinson peptide bioregulator family. It was designed to target pineal gland function, and research suggests it penetrates cell membranes and interacts directly with DNA, modulating gene expression related to neuroprotection and circadian regulation. Its mechanism of action involves upregulation of serotonin synthesis enzymes and modulation of melatonin production pathways in pinealocytes. Research by Khavinson et al. published in Bulletin of Experimental Biology and Medicine demonstrated that Pinealon exhibited neuroprotective effects in cortical neuron cultures exposed to hypoxic and oxidative stress conditions, reducing cell death by up to 40% compared to controls. Additional studies showed that EDR peptide administration in aged animal models helped restore circadian melatonin rhythms that had deteriorated with age. Work published in Advances in Gerontology indicated that Pinealon improved memory consolidation and learning capacity in senescence-accelerated mice. Compared to Epithalon (AEDG), another Khavinson bioregulator peptide targeting the pineal gland, Pinealon operates through distinct mechanisms. While Epithalon primarily activates telomerase and elongates telomeres, Pinealon focuses on direct neuroprotective gene regulation and serotonin pathway support. The two are sometimes studied in conjunction for comprehensive pineal gland and aging research. Lyophilized Pinealon should be stored at -20°C. Reconstitute with bacteriostatic water immediately before use and store at 2-8°C for up to 3 weeks. Researchers in gerontology, chronobiology, and neuroprotection are the primary investigators of this peptide, particularly those studying age-related cognitive decline and circadian disruption.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 20mg of research-grade material.

Research Applications

• Neuroprotection against hypoxia
• Circadian rhythm regulation
• Memory consolidation and learning
• Serotonin pathway research

Specifications

Size

20mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Formula

C15H26N6O8

Molecular Weight

418.41 g/mol

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection