NAD+ 1000mg

Description

High-dose NAD+ coenzyme for comprehensive cellular energy research.

NAD+ (Nicotinamide Adenine Dinucleotide) at 1000mg provides a high-dose research formulation of this essential metabolic coenzyme for comprehensive cellular energy and longevity studies. NAD+ participates in over 500 enzymatic reactions, functioning as the primary electron shuttle in mitochondrial oxidative phosphorylation and as an obligate co-substrate for critical regulatory enzymes including sirtuins, PARPs, and CD38. The age-related decline of NAD+ -- approximately 50% between ages 40 and 60 in certain tissues -- represents one of the most consistent biomarkers of biological aging. Research published in Cell by Zhang et al. (2016) demonstrated that NAD+ repletion in aged mice restored mitochondrial function to youthful levels and improved cardiac function through SIRT3-mediated deacetylation of mitochondrial proteins. Hou et al. in Nature Communications showed that NAD+ augmentation reduced neuroinflammation and improved cognitive function in Alzheimer's disease models through microglial metabolic reprogramming. A comprehensive review by Rajman et al. (2018) in Cell Metabolism catalogued evidence supporting NAD+ supplementation for cardioprotection, neuroprotection, and metabolic restoration across multiple organ systems. This 1000mg formulation is designed for research protocols requiring higher concentrations or larger-volume preparations compared to the 500mg variant. The higher dose allows for extended study durations and dose-response investigations without multiple reconstitutions. Compared to NAD+ precursors (NMN, NR), direct NAD+ is preferred in certain in vitro and ex vivo research settings where biosynthetic pathway variability could confound results. Store lyophilized NAD+ at -20°C in sealed, desiccated vials. Reconstitute with bacteriostatic water and store at 2-8°C, using within 2-3 weeks. NAD+ degrades faster in solution than most peptides, so researchers should prepare working aliquots. Investigated by gerontologists, cardiologists, neuroscientists studying neurodegeneration, and metabolic researchers examining sirtuin biology.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 1000mg of research-grade material.

Research Applications

• Advanced aging and longevity studies
• Cardioprotective research
• Skeletal function and ATP production
• Comprehensive DNA repair studies

Specifications

Size

1000mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Formula

C21H27N7O14P2

Molecular Weight

663.43 g/mol

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection